![](/CAS/GIF/1260585-11-2.gif)
(S)-8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one synthesis
- Product Name:(S)-8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
- CAS Number:1260585-11-2
- Molecular formula:C8H7ClF3N3O
- Molecular Weight:253.61
![2-Amino-4-(trifluoromethyl)pyrimidine](/CAS/GIF/16075-42-6.gif)
16075-42-6
217 suppliers
$8.00/1g
![(S)-8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one](/CAS/GIF/1260585-11-2.gif)
1260585-11-2
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Yield:-
Steps:
Multi-step reaction with 4 steps
1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 24 h / 40 °C
2: sodium methylate / methanol / 1.25 h
3: trichlorophosphate / 1,2-dichloro-ethane / 3 h / 20 - 65 °C
4: chiralpak AD / ethanol; n-heptane
References:
Pasquier, Benoit;El-Ahmad, Youssef;Filoche-Rommé, Bruno;Dureuil, Christine;Fassy, Florence;Abecassis, Pierre-Yves;Mathieu, Magali;Bertrand, Thomas;Benard, Tsiala;Barrière, Cédric;El Batti, Samira;Letallec, Jean-Philippe;Sonnefraud, Véronique;Brollo, Maurice;Delbarre, Laurence;Loyau, Véronique;Pilorge, Fabienne;Bertin, Luc;Richepin, Patrick;Arigon, Jér?me;Labrosse, Jean-Robert;Clément, Jacques;Durand, Florence;Combet, Romain;Perraut, Pierre;Leroy, Vincent;Gay, Frédéric;Lefran?ois, Dominique;Bretin, Fran?ois;Marquette, Jean-Pierre;Michot, Nadine;Caron, Anne;Castell, Christelle;Schio, Laurent;McCort, Gary;Goulaouic, Hélène;Garcia-Echeverria, Carlos;Ronan, Baptiste [Journal of Medicinal Chemistry,2015,vol. 58,# 1,p. 376 - 400]