2-(Di-t-butylphosphino)-3-methoxy-6-methyl-2',4',6'-tri-i-propyl-1,1'-biphenyl synthesis
- Product Name:2-(Di-t-butylphosphino)-3-methoxy-6-methyl-2',4',6'-tri-i-propyl-1,1'-biphenyl
- CAS Number:1262046-34-3
- Molecular formula:C31H49OP
- Molecular Weight:468.69
21524-34-5
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1262046-34-3
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
2.3: 1.5 h / 0 - 20 °C / Inert atmosphere
3.1: tert.-butyl lithium / toluene; pentane / 0.67 h / -78 °C / Inert atmosphere
3.2: 20 h / -78 - 140 °C / Inert atmosphere
References:
Wu, Xiaoxing;Fors, Brett P.;Buchwald, Stephen L. [Angewandte Chemie - International Edition,2011,vol. 50,# 42,p. 9943 - 9947]