1-(3-Bromo-2,5,6-trifluoro-4-methoxyphenyl)-4-propylcyclohexanol synthesis
1synthesis methods
- Product Name:1-(3-Bromo-2,5,6-trifluoro-4-methoxyphenyl)-4-propylcyclohexanol
- CAS Number:1262220-70-1
- Molecular formula:C16H20BrF3O2
- Molecular Weight:381.23
Yield:1262220-70-1 75%
Reaction Conditions:
Stage #1: 1,3-dibromo-2,4,5-trifluoro-6-methoxybenzenewith n-butyllithium in diethyl ether;hexane at -78; for 0.5 h;Inert atmosphere;
Stage #2: 4-propyl-cyclohexanone in diethyl ether;hexane at -78; for 2.5 h;
Stage #3: with water in diethyl ether;hexane;
References:
Kenwright, Alan M.;Sandford, Graham;Tadeusiak, Andrzej J.;Yufit, Dmitrii S.;Howard, Judith A.K.;Kilickiran, Pinar;Nelles, Gabriele [Tetrahedron,2010,vol. 66,# 52,p. 9819 - 9827] Location in patent:experimental part