3-[(E)-(3-CHLOROPHENYL)METHYLIDENE]-2,3-DIHYDRO-4H-CHROMEN-4-ONE synthesis

Yield:1262616-91-0 65%

Reaction Conditions:

with hydrogenchloride in methanol;water; for 24 h;Reflux;

Steps:

4.2. General procedure for the synthesis of 3-benzylidene-4-chromanones derivatives

General procedure: A round-bottom flask was charged with the 4-chromanone (3.4 mmol) and aromatic-aldehyde (3.6 mmol). This was dissolved in methanol (20 mL), and concentrated hydrochloride (10 mL). The mixture was refluxed for 24 h and then diluted with water. Filtration afforded the crude product, which was crystallized from methanol to give the pure product.

References:

Cheng, Xue-Ming;Huang, Zhi-Tang;Zheng, Qi-Yu [Tetrahedron,2011,vol. 67,# 47,p. 9093 - 9098] Location in patent:experimental part