3-Quinolinecarboxylic acid, 1-(4-aMinophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)- synthesis

5synthesis methods

Product Name:3-Quinolinecarboxylic acid, 1-(4-aMinophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-
CAS Number:126362-91-2
Molecular formula:C20H19FN4O3
Molecular Weight:382.39

ethyl 7-chloro-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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3-Quinolinecarboxylic acid, 1-(4-aMinophenyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-

126362-91-2
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Yield:-

Steps:

Multi-step reaction with 4 steps
1: 61 percent / K₂CO₃ / dimethylformamide / 15 h / 100 °C
2: 78 percent / Acetic acid, Hydrochloric acid / 4 h / Heating
3: 74 percent / Pyridine / 67 h / 100 °C
4: 55 percent / Sodium hydroxide, Ferrous sulfate / H₂O / 0.5 h / Heating

References:

Radl, Stanislav;Zikan, Viktor [Collection of Czechoslovak Chemical Communications,1989,vol. 54,# 8,p. 2181 - 2189]

3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxo-7-(1-piperazinyl)-

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3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxo-

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126362-91-2
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3-Quinolinecarboxylic acid, 7-chloro-6-fluoro-1,4-dihydro-1-(4-nitrophenyl)-4-oxo-, ethyl ester

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References

350-46-9 Synthesis

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References