ChemicalBook CAS DataBase List CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester

CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester synthesis

4synthesis methods

Product Name:CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester
CAS Number:1269440-69-8
Molecular formula:C17H24BClFNO4
Molecular Weight:371.64

1996-30-1 Synthesis

1996-30-1
218 suppliers
$5.00/1g

CarbaMic acid, N-[5-chloro-2-fluoro-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-diMethylethyl ester

1269440-69-8
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
1.2: -78 - 20 °C
2.1: diphenylphosphoranyl azide; triethylamine / toluene / 2 h / 75 - 84 °C
2.2: 0.25 h / 35 °C
3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / 100 °C

References:

IRM LLC;NOVARTIS AG;HUANG, Shenlin;JIN, Xianming;LIU, Zuosheng;POON, Daniel;TELLEW, John;WAN, Yongqin;WANG, Xing;XIE, Yongping WO2011/25927, 2011, A1

CarbaMic acid, N-(3-broMo-5-chloro-2-fluorophenyl)-, 1,1-diMethylethyl ester

1269232-94-1
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73183-34-3
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$6.00/5g

1269440-69-8
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References

Benzoic acid, 3-broMo-5-chloro-2-fluoro-

1269232-93-0
52 suppliers
$65.00/250mg

1269440-69-8
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References

Benzaldehyde, 3-broMo-5-chloro-2-fluoro-

1269440-82-5
36 suppliers
$45.00/10mg

1269440-69-8
41 suppliers
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References