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1269514-88-6

2-(Benzyloxy)-4-phenethylisoquinoline-1,3(2H,4H)-dione synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: ammonia; sodium hydride / diethyl ether / 4 h / -35 °C
2: potassium hydroxide / methanol; water / 1 h / Reflux
3: toluene / 12 h / Reflux

References:

Billamboz, Muriel;Bailly, Fabrice;Lion, Cedric;Calmels, Christina;Andreola, Marie-Line;Witvrouw, Myriam;Christ, Frauke;Debyser, Zeger;De Luca, Laura;Chimirri, Alba;Cotelle, Philippe [European Journal of Medicinal Chemistry,2011,vol. 46,# 2,p. 535 - 546]