5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester synthesis
- Product Name:5-Trifluoromethyl-piperidine-3-carboxylic acid methyl ester
- CAS Number:1269755-53-4
- Molecular formula:C8H12F3NO2
- Molecular Weight:211.18
124236-38-0
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$134.31/250mgs:
1269755-53-4
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$456.92/5MG
Yield:1269755-53-4 99.7%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen;acetic acid at 50;
Steps:
PREPARATION OF INTERMEDIATE 114
A hydrogenation flask was charged with AcOH (500 mL) and then 10% palladium on active carbon (19.52 g, 18.34 mmol) was added. Intermediate 113 (18.81 g, 91.69 mmol) was added and the mixture was hydrogenated at 50 °C overnight. The mixture was filtered over dicalite and the filtrate was evaporated to yield intermediate 114 (19.3 g, 99.7% yield), which was used in the next step without further purification
References:
WO2018/154133,2018,A1 Location in patent:Page/Page column 88
131747-40-5
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1269755-53-4
28 suppliers
$456.92/5MG
436799-33-6
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$6.00/250mg
1269755-53-4
28 suppliers
$456.92/5MG