Methanesulfonic acid, trifluoro-, 2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl ester synthesis
- Product Name:Methanesulfonic acid, trifluoro-, 2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl ester
- CAS Number:127175-39-7
- Molecular formula:C11H8F3NO5S
- Molecular Weight:323.25
Yield:127175-39-7 92%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 5 - 20; for 1 h;
Steps:
1
To a solution of 2-(2-hydroxyethyl)isoindoline-1,3-dione (10 mmol, 1.91 g) and DIPEA (10 mmol, 1.29 g) in CH2Cl2, trifluoromethanesulfonic anhydride (1.15 eq, 3.25 g) dropwise were added at 5° C.
The mixture was stirred at room temperature for 1 h.
After this time, the mixture was washed with 5% aqueous solution of NaHCO3 and water.
Layers were separated, the organic one dried over Na2SO4 and evaporated in vacuo to yield 2-(1,3-dioxoisoindolin-2-yl)ethyl trifluoromethanesulfonate as yellow oil (2.94 g, 92%). MS: m/z=324 [M+H]+.
References:
US10689360,2020,B1 Location in patent:Page/Page column 48-49
