tert-Butyl 1-(4-fluorobenzoyl)piperidin-4-ylcarbamate synthesis
- Product Name:tert-Butyl 1-(4-fluorobenzoyl)piperidin-4-ylcarbamate
- CAS Number:1286274-34-7
- Molecular formula:C17H23FN2O3
- Molecular Weight:322.37
456-22-4
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73874-95-0
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1286274-34-7
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Yield: 96.3%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate at 25; for 3 h;
Steps:
10.1 Preparation of tert-butyl (1- (4-fluorobenzoyl) piperidin-4-yl) carbamate
Tert-Butylpiperidin-4-ylcarbamate (2 g, 9.99 mmol) was dissolved in dichloromethane (50 mL)4-Fluorobenzoic acid (1.4 g, 9.99 mmol) was added,2- (7-Azobenzotriazole) -N, N, N ', N'-tetramethyluronium hexafluorophosphate (4.94 g, 12.99 mmol)And N, N-diisopropylethylamine (3.23 g, 24.99 mmol),The reaction was carried out at 25 ° C for 3 hours.The reaction was completed by TLC (petroleum ether: ethyl acetate = 5: 1). The reaction mixture was washed with water (50 mL) and saturated brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated in vacuo to give the product Rate of 96.3%).
References:
Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.;Wu Yongqian;Qi Qu;Zu Chao CN107226808, 2017, A Location in patent:Paragraph 0312-0315
403-43-0
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$9.00/25g
73874-95-0
449 suppliers
$10.00/250mg
1286274-34-7
5 suppliers
$309.00/1g