tert-Butyl 1-(4-chlorobenzyl)piperidin-4-ylcarbamate synthesis

7synthesis methods

Product Name:tert-Butyl 1-(4-chlorobenzyl)piperidin-4-ylcarbamate
CAS Number:1286275-72-6
Molecular formula:C17H25ClN2O2
Molecular Weight:324.85

73874-95-0 Synthesis

73874-95-0
454 suppliers
$10.00/250mg

622-95-7 Synthesis

622-95-7
226 suppliers
$6.00/1g

tert-Butyl 1-(4-chlorobenzyl)piperidin-4-ylcarbamate

1286275-72-6
6 suppliers
$309.00/1g

Yield:1286275-72-6 84%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in dichloromethane at 20;

Steps:

4 Synthesis of Compound 2-d

Compound 1 (200mg, 0.998mmol) was dissolved in DCM (20ml) and then 4-chlorobenzyl bromide (185mg, 0.898mmol) was added thereto.High DIPEA (0.26ml, 1.497mmol) was added thereto and stirred at room temperature. After the reaction was completed, water was added and extracted twice with DCM.The organic layer obtained was dried over anhydrous MgSO 4 and filtered. The filtrate was concentrated under reduced pressure, and then silica column chromatography.Purification by (MC: MeOH = 25: 1) gave the compound 2-d as a pink solid (112 mg, 84%).

References:

KR101548927,2015,B1 Location in patent:Paragraph 0089-0092

104-83-6 Synthesis