ChemicalBook CAS DataBase List 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}[2-(4-methoxyphenyl)ethyl]amino)acetic acid

2-({[(9H-fluoren-9-yl)methoxy]carbonyl}[2-(4-methoxyphenyl)ethyl]amino)acetic acid synthesis

2synthesis methods

Product Name:2-({[(9H-fluoren-9-yl)methoxy]carbonyl}[2-(4-methoxyphenyl)ethyl]amino)acetic acid
CAS Number:1286711-20-3
Molecular formula:C26H25NO5
Molecular Weight:431.48

Glycine, N-[2-(4-methoxyphenyl)ethyl]-, ethyl ester

1021046-51-4
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82911-69-1 Synthesis

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1
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$7.00/25g

2-({[(9H-fluoren-9-yl)methoxy]carbonyl}[2-(4-methoxyphenyl)ethyl]amino)acetic acid

1286711-20-3
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Yield:1286711-20-3 79%

Reaction Conditions:

Stage #1: N-[2-(4-methoxyphenyl)ethyl]glycine ethyl esterwith sodium hydroxide in methanol; for 0.5 h;Inert atmosphere;
Stage #2: N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimidewith hydrogenchloride in 1,4-dioxane;water at 0 - 20;Inert atmosphere;

References:

Einsiedel, Jürgen;Held, Cornelia;Hervet, Maud;Plomer, Manuel;Tschammer, Nuska;Hübner, Harald;Gmeiner, Peter [Journal of Medicinal Chemistry,2011,vol. 54,# 8,p. 2915 - 2923] Location in patent:supporting information; experimental part

55-81-2 Synthesis

55-81-2
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1286711-20-3
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References

2-({[(9H-fluoren-9-yl)methoxy]carbonyl}[2-(4-methoxyphenyl)ethyl]amino)acetic acid Related Search:

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