Methyl-(S)-pyrrolidin-3-yl-carbaMic acid benzyl ester synthesis

2synthesis methods

Product Name:Methyl-(S)-pyrrolidin-3-yl-carbaMic acid benzyl ester
CAS Number:1286768-74-8
Molecular formula:C13H18N2O2
Molecular Weight:234.2942

1-Pyrrolidinecarboxylic acid, 3-[methyl[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3S)-

1412977-80-0
0 suppliers
inquiry

Methyl-(S)-pyrrolidin-3-yl-carbaMic acid benzyl ester

1286768-74-8
6 suppliers
$502.82/5MG

Yield:1286768-74-8 100%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 25; for 16 h;

Steps:

3 Step 3: (S)-Methyl(pyrrolidin-3-yl)carbamate

To (S)-3-(((benzyloxycarbonyl)methyl)amino)pyrrolidine-1-carboxylic acid tert-butyl ester (5.7g, 17mmol) in dichloromethane (100mL) was added trifluoroacetic acid (25mL ),The resulting mixture was stirred at 25°C for 16 hours. The solvent was removed under vacuum to obtain the crude title compound (4.0 g, 100%) as a yellow oil.

References:

CN113354635,2021,A Location in patent:Paragraph 0255; 0262-0264

501-53-1
393 suppliers
$10.00/1g

1286768-74-8
6 suppliers
$502.82/5MG

References