ChemicalBook CAS DataBase List 5-(Toluene-4-sulfonyloxy)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

5-(Toluene-4-sulfonyloxy)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester synthesis

1synthesis methods

Product Name:5-(Toluene-4-sulfonyloxy)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester
CAS Number:1293370-51-0
Molecular formula:C17H23NO5S
Molecular Weight:353.43

4124-41-8 Synthesis

4124-41-8
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98977-36-7 Synthesis

98977-36-7
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5-(Toluene-4-sulfonyloxy)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

1293370-51-0
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Yield:1293370-51-0 64%

Reaction Conditions:

Stage #1: 3-oxo-piperidine-1-carboxylic acid tert-butyl esterwith sodium t-butanolate in tetrahydrofuran at -20 - 20;Inert atmosphere;
Stage #2: p-toluenesulfonylanhydride in tetrahydrofuran at -15 - -5; for 1.5 h;Inert atmosphere;

References:

Reeves, Diana C.;Rodriguez, Sonia;Lee, Heewon;Haddad, Nizar;Krishnamurthy, Dhileepkumar;Senanayake, Chris H. [Organic Letters,2011,vol. 13,# 9,p. 2495 - 2497] Location in patent:supporting information; experimental part