3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazole-4-amine synthesis

5synthesis methods

Product Name:3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazole-4-amine
CAS Number:1313410-25-1
Molecular formula:C17H18N4
Molecular Weight:278.35

3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-4-nitro-1H-indazole

1313410-24-0
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3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazole-4-amine

1313410-25-1
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Yield:1313410-25-1 103 mg

Reaction Conditions:

with hydrogen;palladium in tetrahydrofuran;methanol; for 12 h;

Steps:

1.4 3 -Cyclopropyl- 1 -((6-methylpyridin-2-yl)methyl)- 1 H-indazole-4-amine

Under a hydrogen atmosphere, 3 -cyclopropyl- l-((6-methylpyridin-2-yl)methyl)-4- nitro-1 H-indazole (1 13 mg) was stirred, together with palladium (12 mg), for 12 hrs in tetrahydrofuran/methanol (1/1 , 5 mL). The resulting reaction mixture was vacuum filtered through a Celite pad, and the filtrate was concentrated by distillation to obtain the desired compound (103 mg).

References:

WO2014/3483,2014,A1 Location in patent:Page/Page column 25

2942-40-7 Synthesis