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tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate synthesis

4synthesis methods
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
822 suppliers
$13.50/25G

2897-43-0 Synthesis
2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE

2897-43-0
167 suppliers
$7.00/250mg

tert-butyl (2,6-dichloro-3-nitropyridin-4-yl)carbamate

1313726-52-1
7 suppliers
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Yield:1313726-52-1 100%

Reaction Conditions:

with sodium hexamethyldisilazane in tetrahydrofuran at -70; for 2 h;

References:

Reutershan, Michael H.;MacHacek, Michelle R.;Altman, Michael D.;Bogen, Stephane;Cai, Mingmei;Cammarano, Carolyn;Chen, Dapeng;Christopher, Matthew;Cryan, John;Daublain, Pierre;Fradera, Xavier;Geda, Prasanthi;Goldenblatt, Peter;Hill, Armetta D.;Kemper, Raymond A.;Kutilek, Victoria;Li, Chaomin;Martinez, Michelle;McCoy, Mark;Nair, Latha;Pan, Weidong;Thompson, Christopher F.;Scapin, Giovanna;Shizuka, Manami;Spatz, Marianne L.;Steinhuebel, Dietrich;Sun, Binyuan;Voss, Matthew E.;Wang, Xiao;Yang, Liping;Yeh, Tammie C.;Dussault, Isabelle;Marshall, C. Gary;Trotter, B. Wesley [Journal of Medicinal Chemistry,2021,vol. 64,# 21,p. 16213 - 16241]