Methyl 2-[(4,7-dimethoxy-1H-benzimidazol-1-yl)methyl]nicotinate synthesis
- Product Name:Methyl 2-[(4,7-dimethoxy-1H-benzimidazol-1-yl)methyl]nicotinate
- CAS Number:1315219-77-2
- Molecular formula:C17H17N3O4
- Molecular Weight:327.33
7711-50-4
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Yield:1315219-77-2 77%
Reaction Conditions:
Stage #1: 4,7-dimethoxybenzimidazolewith sodium hydride in N,N-dimethyl-formamide at 80; for 1 h;
Stage #2: 2-chloromethyl-pyridine-3-carboxylic acid methyl ester in N,N-dimethyl-formamide at 80; for 18 h;
References:
Joyce, Eamonn;McArdle, Patrick;Aldabbagh, Fawaz [Synlett,2011,# 8,art. no. D00611ST,p. 1097 - 1100] Location in patent:supporting information; experimental part