DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID synthesis
- Product Name:DIETHYL 1-(2-BROMO-ETHYL)-1H-PYRAZOLE-3,5-DICARBOXYLIC ACID
- CAS Number:131727-29-2
- Molecular formula:C11H15BrN2O4
- Molecular Weight:319.15
106-93-4
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Yield:131727-29-2 85%
Reaction Conditions:
with potassium carbonate in acetonitrile;Reflux;
Steps:
[Dimethyl 1-(2-bromoethyl)-1H-pyrazole-3, 5-dicarboxylate] (3a)
A solution of compound 2a (2.5 g, 11.79 mmol); K2CO3 (1.95 g, 14.15 mmol) and 1, 2-dibromoethane (5.01mL, 58.96 mmol) in acetonitrile (70 mL) was refluxed for 18 h. The reaction mixture was cooled; filtered and the filtrate was evaporated to dryness. The crude product was purified by column chromatography on silica gel (100-200 mesh) using ethyl acetate in hexane to give compound 2 (3.19 g, 85%). MS (ES+) m/z: 320.
References:
Surase, Yogesh B.;Samby, Kirandeep;Amale, Sagar R.;Sood, Ruchi;Purnapatre, Kedar P.;Pareek, Pawan K.;Das, Biswajit;Nanda, Kamna;Kumar, Subodh;Verma, Ashwani K. [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 15,p. 3454 - 3459] Location in patent:supporting information
540-51-2
232 suppliers
$17.00/5g
37687-24-4
167 suppliers
$11.00/1g
131727-29-2
10 suppliers
inquiry