2-(trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-methylpyridine synthesis
- Product Name:2-(trifluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-methylpyridine
- CAS Number:1321518-03-9
- Molecular formula:C13H17BF3NO2
- Molecular Weight:287.09
1620-72-0
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73183-34-3
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Yield:1321518-03-9 83%
Reaction Conditions:
Stage #1: bis(pinacol)diboranewith (1,5-cyclooctadiene)(methoxy)iridium(I) dimer;4,4'-di-tert-butyl-2,2'-bipyridine at 50; for 0.166667 h;Inert atmosphere;
Stage #2: 2-methyl-6-(trifluoromethyl)pyridine at 50; for 6 h;Inert atmosphere;
References:
Congreve, Miles;Andrews, Stephen P.;Doré, Andrew S.;Hollenstein, Kaspar;Hurrell, Edward;Langmead, Christopher J.;Mason, Jonathan S.;Ng, Irene W.;Tehan, Benjamin;Zhukov, Andrei;Weir, Malcolm;Marshall, Fiona H. [Journal of Medicinal Chemistry,2012,vol. 55,# 5,p. 1898 - 1903] Location in patent:experimental part
39890-95-4
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1321518-03-9
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