6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester synthesis
- Product Name:6-(1-Piperazinyl)-3-pyridinecarboxylic acid ethyl ester
- CAS Number:132521-78-9
- Molecular formula:C12H17N3O2
- Molecular Weight:235.28
Yield:132521-78-9 86.6%
Reaction Conditions:
with potassium carbonate in acetonitrile at 100; for 12 h;Inert atmosphere;
Steps:
1.1 1) Synthesis of ethyl 6-piperazinyl nicotinate
Ethyl 6-chloronicotinate (12 g, 0.06 mol, 1.00 equiv), piperazine (8.35 g, 0.10 mol, 1.50 equiv) were dissolved in acetonitrile (100 ml).Potassium carbonate (17.87 g, 0.13 mol, 2.00 equiv) was added and the mixture was refluxed under nitrogen at 100° C. for 12 h.The reaction was monitored by TLC, suction filtered and the filtrate evaporated. Add ethyl acetate, water solution, wash a small amount of water twice,The organic layers were combined, washed with saturated sodium chloride, dried over anhydrous sodium sulfate and allowed to stand. The filtrate was spin-dry,That is, the product 11.63g(Milky white solid) Yield: 86.6%.
References:
CN105017140,2017,B Location in patent:Paragraph 0027; 0028
49608-01-7
265 suppliers
$7.00/5g
57260-71-6
731 suppliers
$5.00/5g
132521-78-9
12 suppliers
inquiry
5326-23-8
544 suppliers
$5.00/1g
132521-78-9
12 suppliers
inquiry