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ChemicalBook CAS DataBase List (2R,4R)-1-(tert-butoxycarbonyl)-4-cyanopyrrolidine-2-carboxylic acid

(2R,4R)-1-(tert-butoxycarbonyl)-4-cyanopyrrolidine-2-carboxylic acid synthesis

3synthesis methods
77450-00-1 Synthesis
(4R)-4-Hydroxy-1-Boc-D-proline ethyl ester

77450-00-1
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(2R,4R)-1-(tert-butoxycarbonyl)-4-cyanopyrrolidine-2-carboxylic acid

132622-85-6
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: 90 percent / CBr4, P(Ph3) / CH2Cl2 / 16 h / 22 °C
2: 22 percent / n-Bu4NCN / dimethylformamide / 20 h / 55 °C
3: 90 percent / 1M NaOH / methanol; H2O / 22 °C

References:

Webb, Thomas R.;Eigenbrot, Charles [Journal of Organic Chemistry,1991,vol. 56,# 9,p. 3009 - 3016]

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