ChemicalBook CAS DataBase List Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(1,1-dimethylethyl)-

Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(1,1-dimethylethyl)- synthesis

12synthesis methods

Product Name:Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(1,1-dimethylethyl)-
CAS Number:132663-73-1
Molecular formula:C10H16O2
Molecular Weight:168.23

124-38-9
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594-19-4
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Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-(1,1-dimethylethyl)-

132663-73-1
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Yield:132663-73-1 87 %

Reaction Conditions:

Stage #1: tert.-butyl lithium;[1.1.1]propellane in diethyl ether at -85;Inert atmosphere;
Stage #2: carbon dioxide in water at 20;Inert atmosphere;

References:

Pickford, Helena D.;Ripenko, Vasyl;McNamee, Ryan E.;Holovchuk, Serhii;Thompson, Amber L.;Smith, Russell C.;Mykhailiuk, Pavel K.;Anderson, Edward A. [Angewandte Chemie - International Edition,2023,vol. 62,# 3,art. no. E202213508][Angew. Chem.,2023,vol. 135,# 3] Location in patent:supporting information

124-38-9
123 suppliers
$214.00/14L