![](/StructureFile/ChemBookStructure3/GIF/CB1115145.gif)
6-AMINO-3-METHYL-4-(3-PYRIDINYL)-1,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE synthesis
- Product Name:6-AMINO-3-METHYL-4-(3-PYRIDINYL)-1,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE
- CAS Number:132813-99-1
- Molecular formula:C13H11N5O
- Molecular Weight:253.26
![3-Pyridinecarboxaldehyde](/CAS/GIF/500-22-1.gif)
500-22-1
466 suppliers
$6.00/5g
![Ethyl acetoacetate](/CAS/GIF/141-97-9.gif)
141-97-9
781 suppliers
$5.00/25g
![Malononitrile](/CAS/GIF/109-77-3.gif)
109-77-3
426 suppliers
$10.00/5g
![6-AMINO-3-METHYL-4-(3-PYRIDINYL)-1,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE](/StructureFile/ChemBookStructure3/GIF/CB1115145.gif)
132813-99-1
13 suppliers
inquiry
Yield:132813-99-1 94%
Reaction Conditions:
with lipase from Aspergillus niger in ethanol at 30; for 1 h;Enzymatic reaction;
Steps:
2.3. General procedure for the synthesis of pyanopyrazoles
General procedure: To a mixture of hydrazine hydrate (80% assay) (1 mmol) andethyl acetoacetate (1 equiv), ethanol (10 mL) was added and stirredvigorously for 5 min to make a homogenous solution. Then aldehyde/ketone (1 equiv), malononitrile (1 equiv), and ANL (20 mg)were added to the solution. After stirring for the specified time at30 C, the starting materials got converted into the desired productand precipitated as solid. After completion, as evident from TLC, thereaction mixture was diluted with 10 mL of warm ethanol (60 C) todissolve the solid products. The suspension was centrifuged to separatethe lipase and the supernatant liquid was decanted from thecentrifuge tube. The liquid, so obtained, was concentrated undervacuum to make a saturated solution. Upon standing the solutionovernight resulted in precipitation of the product which was furtherrecrystallized from ethanol to achieve the pure product.
References:
Bora, Pranjal P.;Bihani, Manisha;Bez, Ghanashyam [Journal of Molecular Catalysis B: Enzymatic,2013,vol. 92,p. 24 - 33]
![3-Pyridinecarboxaldehyde](/CAS/GIF/500-22-1.gif)
500-22-1
466 suppliers
$6.00/5g
![Ethyl acetoacetate](/CAS/GIF/141-97-9.gif)
141-97-9
781 suppliers
$5.00/25g
![Hydrazine hydrate](/CAS/GIF/7803-57-8.gif)
7803-57-8
4 suppliers
$22.78/50g
![Malononitrile](/CAS/GIF/109-77-3.gif)
109-77-3
426 suppliers
$10.00/5g
![6-AMINO-3-METHYL-4-(3-PYRIDINYL)-1,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE](/StructureFile/ChemBookStructure3/GIF/CB1115145.gif)
132813-99-1
13 suppliers
inquiry
![3-Pyridinecarboxaldehyde](/CAS/GIF/500-22-1.gif)
500-22-1
466 suppliers
$6.00/5g
![6-AMINO-3-METHYL-4-(3-PYRIDINYL)-1,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE](/StructureFile/ChemBookStructure3/GIF/CB1115145.gif)
132813-99-1
13 suppliers
inquiry