6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine synthesis

14synthesis methods

Product Name:6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine
CAS Number:133111-56-5
Molecular formula:C21H20ClN
Molecular Weight:321.84

536-38-9 Synthesis

536-38-9
312 suppliers
$9.00/5g

5-Benzyl-3,4-dihydro-3,3-dimethyl-2H-pyrrole

116673-95-1
19 suppliers
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6-(4-Chlorophenyl)-2,3-Dihydro-2,2-DiMethyl-7-Phenyl-1H-Pyrrolizine

133111-56-5
16 suppliers
$503.17/5MG

Yield:133111-56-5 84%

Reaction Conditions:

Stage #1: 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrolewith sodium hydrogencarbonate in methanol;
Stage #2: 4-chlorobenzoylmethyl bromide in methanol; for 20 h;
Stage #3: with water at 40; for 1 h;

References:

Radl, Stanislav;Stach, Jan;Cerny, Josef;Klecan, Ondrej [Collection of Czechoslovak Chemical Communications,2009,vol. 74,# 6,p. 1011 - 1022] Location in patent:experimental part

825-40-1 Synthesis