ChemicalBook CAS DataBase List 1-Piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-N-[(1R)-1-[(7-methyl-1H-indazol-5-yl)methyl]-2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxoethyl]-

1-Piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-N-[(1R)-1-[(7-methyl-1H-indazol-5-yl)methyl]-2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxoethyl]- synthesis

9synthesis methods

Product Name:1-Piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-N-[(1R)-1-[(7-methyl-1H-indazol-5-yl)methyl]-2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxoethyl]-
CAS Number:1337918-83-8
Molecular formula:C36H46N8O3
Molecular Weight:638.8

1H-Indazole-5-propanoic acid, α-[[[4-(1,2-dihydro-2-oxo-3-quinolinyl)-1-piperidinyl]carbonyl]amino]-7-methyl-, (αR)-

928014-62-4
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23995-88-2 Synthesis

23995-88-2
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1-Piperidinecarboxamide, 4-(1,2-dihydro-2-oxo-3-quinolinyl)-N-[(1R)-1-[(7-methyl-1H-indazol-5-yl)methyl]-2-[4-(1-methyl-4-piperidinyl)-1-piperazinyl]-2-oxoethyl]-

1337918-83-8
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Yield:1337918-83-8 85%

Reaction Conditions:

with TBTU;triethylamine in N,N-dimethyl-formamide;

References:

Chaturvedula, Prasad V.;Mercer, Stephen E.;Pin, Sokhom S.;Thalody, George;Xu, Cen;Conway, Charlie M.;Keavy, Deborah;Signor, Laura;Cantor, Glenn H.;Mathias, Neil;Moench, Paul;Denton, Rex;Macci, Robert;Schartman, Richard;Whiterock, Valerie;Davis, Carl;Macor, John E.;Dubowchik, Gene M. [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 11,p. 3157 - 3161]