ChemicalBook CAS DataBase List methyl 5-chloroimidazo[1,2-c]pyrimidine-7-carboxylate

methyl 5-chloroimidazo[1,2-c]pyrimidine-7-carboxylate synthesis

5synthesis methods

Product Name:methyl 5-chloroimidazo[1,2-c]pyrimidine-7-carboxylate
CAS Number:1339891-76-7
Molecular formula:C8H6ClN3O2
Molecular Weight:211.61

7252-83-7 Synthesis

7252-83-7
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Methyl 6-amino-2-chloropyrimidine-4-carboxylate

944129-00-4
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methyl 5-chloroimidazo[1,2-c]pyrimidine-7-carboxylate

1339891-76-7
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Yield:1339891-76-7 55%

Reaction Conditions:

in acetonitrile at 120; for 1 h;Microwave irradiation;

Steps:

GGG.2 Step 2: Synthesis of methyl 5-chloroimidazo[1,2-c]pyrimidine-7-carboxylate

A mixture of methyl 6-amino-2-chloropyrimidine-4-carboxylate (260 mg, 1.39 mmol, 1.00 equiv) and 2-bromo-1,1-dimethoxyethane (1.1 g, 6.51 mmol, 4.00 equiv) in acetonitrile (6 mL) was irradiated with microwave radiation for 1 h at 120° C.
The solids were collected by filtration to give the title compound (162 mg, 55%) as an off-white solid. LC-MS (ES, m/z): 212 [M+H]

References:

US2015/57260,2015,A1 Location in patent:Paragraph 0673; 0674

Imidazo[1,2-c]pyrimidine-7-carboxylic acid, 5,6-dihydro-5-oxo-, methyl ester

1339891-74-5
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1339891-76-7
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References

7-chloro-5-(methylsulfanyl)imidazo[1,2-c]pyrimidine hydrochloride

1339891-11-0
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1339891-76-7
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References

6299-85-0 Synthesis

Methyl 2,4-dichloropyrimidine-6-carboxylate

6299-85-0
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1339891-76-7
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References

56817-09-5
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$155.00/50mg

1339891-76-7
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References