3-Azaspiro[5.5]undecane-9-acetic acid, 3-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester synthesis

Yield:1346229-41-1 91%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 35 - 40; under 2585.81 Torr; for 24 h;

References:

Cox, Jason M.;Chu, Hong D.;Chelliah, Mariappan V.;Debenham, John S.;Eagen, Keith;Lan, Ping;Lombardo, Matthew;London, Clare;Plotkin, Michael A.;Shah, Unmesh;Sun, Zhongxiang;Vaccaro, Henry M.;Venkatraman, Srikanth;Suzuki, Takao;Wang, Nengxue;Ashley, Eric R.;Crespo, Alejandro;Madeira, Maria;Leung, Dennis H.;Alleyne, Candice;Ogawa, Aimie M.;Souza, Sarah;Thomas-Fowlkes, Brande;Di Salvo, Jerry;Weinglass, Adam;Kirkland, Melissa;Pachanski, Michele;Powles, Mary Ann;Tozzo, Effie;Akiyama, Taro E.;Ujjainwalla, Feroze;Tata, James R.;Sinz, Christopher J. [ACS Medicinal Chemistry Letters,2017,vol. 8,# 1,p. 49 - 54] Location in patent:supporting information