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Acetamide, N-(1R)-3-cyclohexen-1-yl-2,2,2-trifluoro- synthesis

6synthesis methods
tert-butyl N-[(1R)-cyclohex-3-en-1-yl]carbamate

1350636-87-1
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Acetamide, N-(1R)-3-cyclohexen-1-yl-2,2,2-trifluoro-

1350636-90-6
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-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: hydrogenchloride / 1,4-dioxane / 20 - 25 °C
2.1: triethylamine / dichloromethane / 0.17 h / 20 °C
2.2: 20 °C

References:

NABRIVA THERAPEUTICS AG;RIEDL, Rosemarie;HEILMAYER, Werner;SPENCE, Lee;BULUSU, Atchyuta, Rama, Chandra, Murty WO2011/146953, 2011, A1