4-Chloro-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine synthesis

2synthesis methods

Product Name:4-Chloro-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS Number:1350639-97-2
Molecular formula:C12H7ClFN3
Molecular Weight:247.66

1H-Pyrrole-3-carboxylic acid, 2-amino-5-(4-fluorophenyl)-, ethyl ester

1181313-55-2
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4-Chloro-6-(4-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine

1350639-97-2
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: formic acid / N,N-dimethyl-formamide / 20 h / 150 °C
2.1: trichlorophosphate / 3 h / 90 °C
2.2: pH 12

References:

Kaspersen, Svein Jacob;Sorum, Christopher;Willassen, Veronica;Fuglseth, Erik;Kjobli, Eli;Bjorkoy, Geir;Sundby, Eirik;Hoff, Brd Helge [European Journal of Medicinal Chemistry,2011,vol. 46,# 12,p. 6002 - 6014]

403-29-2 Synthesis

403-29-2
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1350639-97-2
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References