![](/CAS/20180527/GIF/1350816-24-8.gif)
8-FLUORO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-2,5-DIONE synthesis
- Product Name:8-FLUORO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-2,5-DIONE
- CAS Number:1350816-24-8
- Molecular formula:C10H8FNO2
- Molecular Weight:193.17
![methyl 2-amino-4-fluorobenzoate](/CAS/GIF/2475-81-2.gif)
2475-81-2
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$19.00/1g
![8-FLUORO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-2,5-DIONE](/CAS/20180527/GIF/1350816-24-8.gif)
1350816-24-8
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C
2.1: potassium tert-butylate / tetrahydrofuran / 10 °C
2.2: 20 °C / pH 4
3.1: water / dimethyl sulfoxide / 150 °C / Cooling
3.2: 0 °C
References:
Duffey, Matthew O.;Vos, Tricia J.;Adams, Ruth;Alley, Jennifer;Anthony, Justin;Barrett, Cynthia;Bharathan, Indu;Bowman, Douglas;Bump, Nancy J.;Chau, Ryan;Cullis, Courtney;Driscoll, Denise L.;Elder, Amy;Forsyth, Nancy;Frazer, Jonathan;Guo, Jianping;Guo, Luyi;Hyer, Marc L.;Janowick, David;Kulkarni, Bheemashankar;Lai, Su-Jen;Lasky, Kerri;Li, Gang;Li, Jing;Liao, Debra;Little, Jeremy;Peng, Bo;Qian, Mark G.;Reynolds, Dominic J.;Rezaei, Mansoureh;Scott, Margaret Porter;Sells, Todd B.;Shinde, Vaishali;Shi, Qiuju Judy;Sintchak, Michael D.;Soucy, Francois;Sprott, Kevin T.;Stroud, Stephen G.;Nestor, Michelle;Visiers, Irache;Weatherhead, Gabriel;Ye, Yingchun;Damore, Natalie [Journal of Medicinal Chemistry,2012,vol. 55,# 1,p. 197 - 208]