![](/CAS/20180808/GIF/1352328-64-3.gif)
Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)- synthesis
- Product Name:Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-
- CAS Number:1352328-64-3
- Molecular formula:C31H44O4
- Molecular Weight:480.68
![3alpha-Hydroxy-7-oxo-5beta-cholanic Acid](/CAS/20180906/GIF/4651-67-6.gif)
4651-67-6
329 suppliers
$39.00/500mg
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
423 suppliers
$10.00/10g
![Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-](/CAS/20180808/GIF/1352328-64-3.gif)
1352328-64-3
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Yield:1352328-64-3 98.1%
Reaction Conditions:
Stage #1: 7-Ketolithocholic acidwith potassium carbonate in tetrahydrofuran; for 1 h;Reflux;
Stage #2: benzyl bromide in tetrahydrofuran; for 12 h;
Steps:
4.a a) Preparation of benzyl 3α-hydroxy-7-oxo-5β-cholanoic acid ester
3α-Hydroxy-7-oxo-5β-cholanoic acid (39.0 g, 100 mmol),Potassium carbonate (15.2g110mmol)Soluble in 200ml tetrahydrofuran,The mixture was warmed to reflux with stirring and the reaction was incubated for 1 hour.Benzyl bromide (18.0 g, 105 mmol) was slowly added dropwise.After dropping,Incubation reaction for 12 hours.Cool to room temperature, suction filtration, concentration of the filtrate,3α-Hydroxy-7-oxo-5β-cholanoic acid benzyl ester(471.6 g, yield 98.1%).
References:
CN107383139,2017,A Location in patent:Paragraph 0029
![3alpha-Hydroxy-7-oxo-5beta-cholanic Acid](/CAS/20180906/GIF/4651-67-6.gif)
4651-67-6
329 suppliers
$39.00/500mg
![Benzyl chloride](/CAS/GIF/100-44-7.gif)
100-44-7
626 suppliers
$13.50/250G
![Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-](/CAS/20180808/GIF/1352328-64-3.gif)
1352328-64-3
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![Chenodeoxycholic acid](/CAS/GIF/474-25-9.gif)
474-25-9
651 suppliers
$20.80/5G
![Cholan-24-oic acid,3-hydroxy-7-oxo-, phenylmethyl ester,(3α,5β)-](/CAS/20180808/GIF/1352328-64-3.gif)
1352328-64-3
9 suppliers
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