(2E)-1-(1-Hydroxynaphthalen-2-yl)-3-[3-methoxy-4-(pyrrolidin-1-yl)phenyl]prop-2-en-1-one synthesis

1synthesis methods

Product Name:(2E)-1-(1-Hydroxynaphthalen-2-yl)-3-[3-methoxy-4-(pyrrolidin-1-yl)phenyl]prop-2-en-1-one
CAS Number:1353224-57-3
Molecular formula:C24H23NO3
Molecular Weight:373.44

3-methoxy-4-(1-pyrrolidinyl)benzaldehyde(SALTDATA: FREE)

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711-79-5
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(2E)-1-(1-Hydroxynaphthalen-2-yl)-3-[3-methoxy-4-(pyrrolidin-1-yl)phenyl]prop-2-en-1-one

1353224-57-3
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Yield:1353224-57-3 53%

Reaction Conditions:

with barium(II) hydroxide in methanol at 40; for 12 h;

References:

Chiruta, Chandramouli;Schubert, David;Dargusch, Richard;Maher, Pamela [Journal of Medicinal Chemistry,2012,vol. 55,# 1,p. 378 - 389] Location in patent:supporting information; experimental part