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1354691-47-6

[(3S)-3-hydroxypyrrolidin-1-yl](oxan-4-yl)Methanone synthesis

2synthesis methods
40191-32-0 Synthesis
Tetrahydro-2H-pyran-4-carbonyl chloride

40191-32-0
130 suppliers
$18.00/1g

100243-39-8 Synthesis
(S)-3-Hydroxypyrrolidine

100243-39-8
284 suppliers
$10.00/1g

[(3S)-3-hydroxypyrrolidin-1-yl](oxan-4-yl)Methanone

1354691-47-6
26 suppliers
inquiry

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Yield:1354691-47-6 100%

Reaction Conditions:

with triethylamine in dichloromethane at 0; for 2 h;Inert atmosphere;

References:

Methot, Joey L.;Zhou, Hua;Kattar, Sam D.;Mcgowan, Meredeth A.;Wilson, Kevin;Garcia, Yudith;Deng, Yongi;Altman, Michael;Fradera, Xavier;Lesburg, Charles;Fischmann, Thierry;Li, Chaomin;Alves, Steve;Shah, Sanjiv;Fernandez, Rafael;Goldenblatt, Peter;Hill, Armetta;Shaffer, Lynsey;Chen, Dapeng;Tong, Vince;Mcleod, Robbie L.;Yu, Hongshi;Bass, Alan;Kemper, Ray;Gatto, Nicholas T.;Lafranco-Scheuch, Lisa;Trotter, Benjamin Wesley;Guzi, Timothy;Katz, Jason D. [Journal of Medicinal Chemistry,2019,vol. 62,# 9,p. 4370 - 4382]

40191-32-0 Synthesis
Tetrahydro-2H-pyran-4-carbonyl chloride

40191-32-0
130 suppliers
$18.00/1g

122536-94-1 Synthesis
(S)-3-Hydroxypyrrolidine hydrochloride

122536-94-1
334 suppliers
$7.00/5g

[(3S)-3-hydroxypyrrolidin-1-yl](oxan-4-yl)Methanone

1354691-47-6
26 suppliers
inquiry