Ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole-3-carboxylate synthesis
- Product Name:Ethyl 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole-3-carboxylate
- CAS Number:1355249-29-4
- Molecular formula:C14H15IN2O3
- Molecular Weight:386.18
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Yield:1355249-29-4 58%
Reaction Conditions:
with potassium carbonate in acetonitrile at 60;
Steps:
15.C
Example 15, Step C [00154] To a solution of compound 15c (38 g, 143 mmol) in acetonitrile (380 mL) at r.t. was added K2C03 (39.5 g, 286 mmol) and then PMBCI (24 mL, 177 mmol). The reaction mixture was stirred at 60°C overnight. After cooling to r.t., the mixture was filtered and concentrated under reduced pressure. The residue was purified by chromatography on silica gel to afford compound 15d (32 g, 58%).[00155] This compound was characterized by proton NMR (1HNMR) and mass spectroscopy (MS) in accordance with the procedures described herein. Proton NMR yielded the following results: 1H NMR (DMSO-d6, 400MHz): δ 8.13(s, 1 H), 7.23(d, J = 8.8 Hz, 2H), 6.90(d, J = 8.8 Hz, 2H), 5.29(s, 2H), 4.24 (q, J = 6.8 Hz, 2H), 3.71 (s, 3H); 1.26(t, J = 6.8 Hz, 3H). Mass spectroscopy indicated MS (ESI): m/z 387 (M+H)+.
References:
WO2012/6760,2012,A1 Location in patent:Page/Page column 47-48
179692-08-1
71 suppliers
$13.00/250mg
824-94-2
442 suppliers
$24.19/5G
1355249-29-4
27 suppliers
$65.00/100mg
![1H-Pyrazole-5-carboxylic acid, 4-iodo-1-[(4-methoxyphenyl)methyl]-, ethyl ester](/CAS/20210305/GIF/1355336-09-2.gif)
1355336-09-2
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179692-08-1
71 suppliers
$13.00/250mg
824-94-2
442 suppliers
$24.19/5G
1355249-29-4
27 suppliers
$65.00/100mg
1355336-09-2
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5932-27-4
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1355249-29-4
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623-47-2
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1355249-29-4
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