Cyclopropanecarboxylic acid, 2-(4-nitrophenyl)-, (1R,2R)- synthesis
- Product Name:Cyclopropanecarboxylic acid, 2-(4-nitrophenyl)-, (1R,2R)-
- CAS Number:1356600-07-1
- Molecular formula:C10H9NO4
- Molecular Weight:207.18
3471-10-1
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1356600-07-1
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Yield:1356600-07-1 78.2%
Reaction Conditions:
with nitric acid at 0 - 20; for 3.5 h;
Steps:
13
Intermediate 27: 2R)-2-(4-Nitrophenyl)cyclopropanecarboxylic acidTo a 1000 mL RB flask fitted with magnetic stirrer was charged with 150 mL of HN03, cooled to 0 , was added (1 R,2R)-2-phenylcycloprop anecarboxylic acid (15 g, 92.593 mmol) portion wise for half an hour, RM brought to RT and stirred for 3 h. After the completion of reaction, RM was poured into ice cold water, stirred for 30 min and filtered off the product and dried under vacuum. The obtained product was white color solid (15 g, yield: 78.2%).
References:
WO2012/11125,2012,A1 Location in patent:Page/Page column 79-80