ethyl(R)-2-(7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetatehydrochloride synthesis

3synthesis methods

Product Name:ethyl(R)-2-(7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetatehydrochloride
CAS Number:1360470-80-9
Molecular formula:C16H21ClN2O2
Molecular Weight:308.81

ethyl (7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-acetate

1360470-70-7
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ethyl(R)-2-(7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetatehydrochloride

1360470-80-9
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$1784.00/1g

Yield:1360470-80-9 76%

Reaction Conditions:

Stage #1: ethyl (7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-acetatewith CDX-017 enzyme;pyridoxal 5'-phosphate in water;dimethyl sulfoxide at 45; pH=8.5; for 52 h;Inert atmosphere;triethanolamine/isopropylamine buffer;Enzymatic reaction;
Stage #2: with hydrogenchloride in ipa; pH=6; for 2 h;Inert atmosphere;optical yield given as %ee;enantioselective reaction;

References:

Molinaro, Carmela;Bulger, Paul G.;Lee, Ernest E.;Kosjek, Birgit;Lau, Stephen;Gauvreau, Danny;Howard, Melissa E.;Wallace, Debra J.;O'Shea, Paul D. [Journal of Organic Chemistry,2012,vol. 77,# 5,p. 2299 - 2309] Location in patent:supporting information; experimental part

ethyl 3-[3-(2-ethoxy-2-oxoethyl)-1H-indol-2-yl]propanoate

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1360470-80-9
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3-Pyridazinepropanoic acid, 1,4,5,6-tetrahydro-6-oxo-1-phenyl-, ethyl ester

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1360470-80-9
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References