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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List (1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride

(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride synthesis

4synthesis methods
Cyclopropanecarboxylic acid, 1-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2-formyl-, ethyl ester, (1R,2R)-

1152134-41-2
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(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride

1360828-80-3
66 suppliers
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-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: 2,6-dimethylpyridine; diethylamino-sulfur trifluoride / dichloromethane / 12 h / 10 - 20 °C
2: sodium hydroxide / 20 °C
3: dmap; 2,6-dimethylpyridine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / acetonitrile / 16 h / 15 - 25 °C / Large scale
4: hydrogenchloride / Isopropyl acetate; isopropyl alcohol / 40 h / 0 - 20 °C / Large scale

References:

Cink, Russell D.;Lukin, Kirill A.;Bishop, Richard D.;Zhao, Gang;Pelc, Matthew J.;Towne, Timothy B.;Gates, Bradley D.;Ravn, Matthew M.;Hill, David R.;Ding, Chen;Cullen, Steven C.;Mei, Jianzhang;Leanna, M. Robert;Henle, Jeremy;Napolitano, José G.;Nere, Nandkishor K.;Chen, Shuang;Sheikh, Ahmad;Kallemeyn, Jeffrey M. [Organic Process Research and Development,2020,vol. 24,# 2,p. 183 - 200]

259217-95-3 Synthesis
Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-ethenyl-, ethyl ester, (1R,2S)-

259217-95-3
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(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride

1360828-80-3
66 suppliers
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References
1152134-45-6 Synthesis
(1R,2R)-1-(tert-butoxycarbonylamino)-2-(difluoromethyl)cyclopropanecarboxylic acid

1152134-45-6
18 suppliers
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(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride

1360828-80-3
66 suppliers
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References
Cyclopropanecarboxylic acid, 1-[bis[(1,1-dimethylethoxy)carbonyl]amino]-2-(difluoromethyl)-, ethyl ester, (1R,2R)-

1152134-42-3
0 suppliers
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(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride

1360828-80-3
66 suppliers
inquiry

References

(1R,2R)-1-amino-2-(difluoromethyl)-N-(1-methylcyclopropylsulfonyl)cyclopropanecarboxamide hydrochloride Related Search:

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