Methyl (2Z)-3-(3-bromo-4-fluorophenyl)-2-acetamidoprop-2-enoate synthesis
- Product Name:Methyl (2Z)-3-(3-bromo-4-fluorophenyl)-2-acetamidoprop-2-enoate
- CAS Number:1361513-61-2
- Molecular formula:C12H11BrFNO3
- Molecular Weight:316.12
89524-99-2
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Yield:1361513-61-2 64%
Reaction Conditions:
Stage #1: methyl 2-acetylamino-2-(dimethoxyphosphinyl)acetatewith 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane at 20; for 0.25 h;Inert atmosphere;
Stage #2: 3-bromo-4-fluorobenzaldehyde in dichloromethane at 20;Inert atmosphere;
References:
Etayo, Pablo;Nunez-Rico, Jose Luis;Fernandez-Perez, Hector;Vidal-Ferran, Anton [Chemistry - A European Journal,2011,vol. 17,# 50,p. 13978 - 13982] Location in patent:supporting information; experimental part