Bicyclo[2.2.1]hept-2-ene-2-carboxylic acid, methyl ester, (1S)- (9CI) synthesis
1synthesis methods
- Product Name:Bicyclo[2.2.1]hept-2-ene-2-carboxylic acid, methyl ester, (1S)- (9CI)
- CAS Number:136520-60-0
- Molecular formula:C9H12O2
- Molecular Weight:152.19
Yield:136520-60-0 47%
Reaction Conditions:
Stage #1: norbornenewith N,N,N',N'',N'''-pentamethyldiethylenetriamine;potassium tert-butylate in diethyl ether;hexane at 0;Inert atmosphere;Schlenk technique;
Stage #2: methyl chloroformatewith lithium bromide in tetrahydrofuran at -78;Inert atmosphere;Schlenk technique;
References:
Wang, Yuntao;Liu, Jialin;Huang, Lin;Zhu, Ranran;Huang, Xueyan;Moir, Ross;Huang, Jianhui [Chemical Communications,2017,vol. 53,# 33,p. 4589 - 4592] Location in patent:supporting information