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ChemicalBook CAS DataBase List 5-CHLORO-1,3-DIHYDRO-2H-PYRROLO[3,2-B] PYRIDIN-2-ONE
136888-08-9

5-CHLORO-1,3-DIHYDRO-2H-PYRROLO[3,2-B] PYRIDIN-2-ONE synthesis

2synthesis methods
16013-85-7 Synthesis
2,6-Dichloro-3-nitropyridine

16013-85-7
482 suppliers
$9.00/5g

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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydride / 1,2-dimethoxyethane / 2 h / 20 °C
1.2: 18 h / 20 °C
2.1: hydrogen / ethanol; water / 48 h / 2280.15 Torr
2.2: 5 h / Reflux

References:

Hoffmann-La Roche Inc.;Alam, Muzaffar;Du Bois, Daisy Jo;Hawley, Ronald Charles;Minatti, Ana Elena;Kennedy-Smith, Joshua;Thakkar, Kshitij Chhabilbhai;Wilhelm, Robert Stephen US2013/158066, 2013, A1

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