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2H-Pyrrolo[3,2-b]pyridin-2-one,6-fluoro-1,3-dihydro-(9CI) synthesis

6synthesis methods
136888-21-6 Synthesis
2-CHLORO-5-FLUORO-3-NITROPYRIDINE

136888-21-6
146 suppliers
$6.00/100mg

2H-Pyrrolo[3,2-b]pyridin-2-one,6-fluoro-1,3-dihydro-(9CI)

136888-22-7
31 suppliers
inquiry

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Yield:-

Steps:

Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, RT, 0.25 h, 2.) DMF, 0 deg C, 0.25 h
2: H2 / Raney nickel / aq. ethanol / 2280 Torr
3: 6 N HCl / 3 h / Heating

References:

Robinson, Ralph P.;Donahue, Kathleen M.;Son, Paul S.;Wagy, Steven D. [Journal of Heterocyclic Chemistry,1996,vol. 33,# 2,p. 287 - 293]