2-Propenoic acid, 3-[3-(acetylamino)-6-chloro-2-fluorophenyl]-, ethyl ester, (2E)- synthesis

3synthesis methods

Product Name:2-Propenoic acid, 3-[3-(acetylamino)-6-chloro-2-fluorophenyl]-, ethyl ester, (2E)-
CAS Number:1379666-57-5
Molecular formula:C13H13ClFNO3
Molecular Weight:285.7

867-13-0
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Acetamide, N-(4-chloro-2-fluoro-3-formylphenyl)-

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2-Propenoic acid, 3-[3-(acetylamino)-6-chloro-2-fluorophenyl]-, ethyl ester, (2E)-

1379666-57-5
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Yield:-

Reaction Conditions:

with sodium hydroxide in toluene at 0 - 25;Wittig Olefination;

Steps:

2

Sodium hydroxide (5.3 g, 0.22 mol) was added at 0°C to a solution of N-(4-chloro-2-fluoro-3-formylphenyl)acetamide and ethyl-2-(diethoxylphosphoryl)acetate (37.6 g, 0.17 mol) in toluene (500 mL). The obtained solution was stirred for 2 hours at room temperature (25°C). The reaction was terminated with saturated ammonium chloride, and the reaction mixture was extracted three times with 300 mL of ethyl acetate. The organic phase was separated, dried and concentrated to obtain a crude product, which was used for the next step without purification.

References:

EP2647622,2013,A1 Location in patent:Paragraph 0140

57946-56-2 Synthesis

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References

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References