[1,2,4]Triazolo[1,5-a]pyridine, 7-broMo-2-(1-Methylethyl)- synthesis
- Product Name:[1,2,4]Triazolo[1,5-a]pyridine, 7-broMo-2-(1-Methylethyl)-
- CAS Number:1380331-40-7
- Molecular formula:C9H10BrN3
- Molecular Weight:240.1
1202704-61-7
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1380331-40-7
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Yield:1380331-40-7 30.6%
Reaction Conditions:
with pyridine at 100; for 18 h;
Steps:
34.a
a) 7-bromo-2-isopropyl-[1,2,4]triazolo[1,5-a]pyridine A mixture of 1,2-diamino-4-bromopyridinium2,4,6-trimethylbenzenesulfonate (2 g, 5.15 mmol) and isobutyryl chloride (809 μl, 7.73 mmol) in pyridine (12 ml) is stirred for 18 hours at 100° C. The solvent is evaporated and the orange residue triturated for 2 hrs with sat. aqueous sodium hydrogen carbonate solution. The solid is collected by filtration, washed several times with water and dried affording 7-bromo-2-isopropyl-[1,2,4]triazolo[1,5-a]pyridine (378 mg, 30.6%) as a light brown solid. MS: m/z=240; 242 (M+H+).
References:
US2012/142665,2012,A1 Location in patent:Page/Page column 31
84249-14-9
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1380331-40-7
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$155.00/250mg