4,6-diphenyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidine synthesis
- Product Name:4,6-diphenyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrimidine
- CAS Number:1381862-91-4
- Molecular formula:C28H27BN2O2
- Molecular Weight:434.34
Yield: 82%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in dichloromethane;N,N-dimethyl-formamide at 100;
Steps:
1.1 Synthesis of intermediate product (A)
2- (3-bromophenyl) -4,6-diphenyl-pyrimidine 5.00 g (12.9 mmol), bis (pinacolato) diboron 3.94 g (15.5 mmol), PdCl2 (dppf), in H2Cl2 527 mg (0.645 an mmol) potassium acetate and 3.80 g (38.7 mmol) was heated and stirred at 100 was placed in 100 mL DMF. After the reaction was cooled to ambient temperature and concentrated to pass through the silica gel to a vacuum filter and the filtrate under reduced pressure. Purification through recrystallization of the product from ethyl acetate / toluene conditions to give the desired intermediate compound (A) 4.59 g (82% yield).
References:
CHEIL INDUSTRIES INC.;SAMSUNG ELECTRONICS CO. LTD.;JONG, YOUNG SIK;KANG, HO SEOK;CHOI, HYEON HO;KIM, SANG MO;SON, JUN MO;HWANG, KYU YEONG KR101593182, 2016, B1 Location in patent:Paragraph 0427; 0428; 0432; 0433
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