N-methyl-2-(phenylethynyl)-4-(trifluoromethyl)aniline synthesis

3synthesis methods

Product Name:N-methyl-2-(phenylethynyl)-4-(trifluoromethyl)aniline
CAS Number:1383543-76-7
Molecular formula:C16H12F3N
Molecular Weight:275.27

(2-Iodo-4-trifluoromethyl-phenyl)-methyl-amine

1268238-74-9
3 suppliers
inquiry

N-methyl-2-(phenylethynyl)-4-(trifluoromethyl)aniline

1383543-76-7
3 suppliers
inquiry

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine / tetrahydrofuran / 6 h / 55 °C / Inert atmosphere
1.2: 1 h / 20 °C / Inert atmosphere
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine / tetrahydrofuran / 6 h / 55 °C / Inert atmosphere

References:

Arora, Ramon;Lautens, Mark;Rodríguez, José F.;Whyte, Andrew [Angewandte Chemie - International Edition,2022,vol. 61,# 1,art. no. E202112288][Angew. Chem.,2022,vol. 134,# 1]

1268238-74-9
3 suppliers
inquiry

536-74-3 Synthesis

536-74-3
295 suppliers
$10.00/1g

1383543-76-7
3 suppliers
inquiry

References

163444-17-5
179 suppliers
$9.00/5g

1383543-76-7
3 suppliers
inquiry

References