7-CHLORO-5-METHYLPYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE synthesis

Yield:138904-34-4 87%

Reaction Conditions:

Stage #1: 7-hydroxy-5-methylpyrazolo<1,5-a>pyrimidine-3-carbonitrilewith pyridine;trichlorophosphate at 85 - 120; for 1 h;
Stage #2: in chloroform at 60; for 1 h;
Stage #3: in chloroform;water at 0;

References:

Xu, Jingli;Liu, Hang;Li, Guixia;He, Yong;Ding, Rui;Wang, Xiao;Feng, Man;Zhang, Shuting;Chen, Yurong;Li, Shilei;Zhao, Mingxia;Qi, Chuanmin;Dang, Yonghong [Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,# 16,p. 4736 - 4741] Location in patent:scheme or table