Benzenesulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-4-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]- synthesis
- Product Name:Benzenesulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-4-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]-
- CAS Number:1394293-75-4
- Molecular formula:C19H17F3N4O4S
- Molecular Weight:454.42
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Yield:-
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in tetrahydrofuran at 20; for 16 h;
Steps:
4.2.3. General experimental procedure for compounds 2a and 15a-i
General procedure: Method B: Amine 14 (15 mg, 0.056 mmol) was coevaporated with anhydrous toluene (3 × 3 mL) and dissolved in anhydrous THF (2 mL). Diisoproylethylamine (40 μL, 0.224 mmol) and corresponding isocyanate (0.224 mmol) were added. After stirring for 16 h at room temperature, the reaction mixture was evaporated to dryness. The resulting residue was purified by silica gel column chromatography (0-6% MeOH in EtOAc, v/v) to afford target compounds 15a, 15c and 15g as solid materials.
References:
Costanzi, Stefano;Santhosh Kumar;Balasubramanian, Ramachandran;Kendall Harden;Jacobson, Kenneth A. [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 17,p. 5254 - 5261]
19947-75-2
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184644-22-2
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