![](/CAS/20180713/GIF/139504-50-0.gif)
Mertansine synthesis
- Product Name:Mertansine
- CAS Number:139504-50-0
- Molecular formula:C35H48ClN3O10S
- Molecular Weight:738.29
![DM1-Sme](/CAS/20181012/GIF/138148-68-2.gif)
138148-68-2
49 suppliers
$35.00/1mg
![Mertansine](/CAS/20180713/GIF/139504-50-0.gif)
139504-50-0
204 suppliers
$66.00/2mg
Yield:139504-50-0 4.1 g
Reaction Conditions:
with 1,4-dithio-L-threitol in methanol;ethyl acetate at 20; for 3.5 h;Inert atmosphere;
Steps:
1.4 Step (4)
The crude compound DM1-3L (5g) and DL-dithiothreitol (5.1g) were mixed and dissolved with ethyl acetate (120ml) and methanol (120ml), and phosphate buffer (120mM, pH=7.5, 120ml) was added, Under argon protection, react at room temperature for 3.5 hours, add phosphate buffer (pH=6.0, 240ml), extract with ethyl acetate, wash the organic phase with water, concentrate under reduced pressure to dryness, and separate by column chromatography to obtain compound DM1 (4.1g) ).
References:
Shanghai Pharmaceutical Group Co., Ltd.;Xia Guangbing;Zhu Yang;Zhou Wei;Yao Junliang;Yao Changliang;Liu Junyao;Xia Guangxin;Liu Yanjun CN111978332, 2020, A Location in patent:Paragraph 0074; 0085-0106
![Maytansinol](/CAS/20181212/GIF/57103-68-1.gif)
57103-68-1
174 suppliers
$50.00/5mg
![Mertansine](/CAS/20180713/GIF/139504-50-0.gif)
139504-50-0
204 suppliers
$66.00/2mg
![(S)-2-(N-Methyl-3-(Methyldisulfanyl)propanaMido)propanoic acid](/CAS/20150408/GIF/138148-62-6.gif)
138148-62-6
34 suppliers
inquiry
![Mertansine](/CAS/20180713/GIF/139504-50-0.gif)
139504-50-0
204 suppliers
$66.00/2mg
![(S)-2-(N-Methyl-3-(Methyldisulfanyl)propanaMido)propanoic acid](/CAS/20150408/GIF/138148-62-6.gif)
138148-62-6
34 suppliers
inquiry
![Maytansinol](/CAS/20181212/GIF/57103-68-1.gif)
57103-68-1
174 suppliers
$50.00/5mg
![Mertansine](/CAS/20180713/GIF/139504-50-0.gif)
139504-50-0
204 suppliers
$66.00/2mg