ChemicalBook CAS DataBase List 6-bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carbonitrile

6-bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carbonitrile synthesis

6synthesis methods

Product Name:6-bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carbonitrile
CAS Number:1400580-14-4
Molecular formula:C8H3BrClN3
Molecular Weight:256.49

35302-72-8
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$10.00/5g

6-bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carbonitrile

1400580-14-4
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Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: bromine; iodine / tetrachloromethane / 0.67 h / 0 °C
2.1: sodium / 0.17 h
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.75 h / 20 °C / Inert atmosphere
3.2: 0.5 h / 20 °C
3.3: 0.5 h
4.1: isopropyl alcohol / 3 h / 85 °C
4.2: 5 h / 85 °C
5.1: trichlorophosphate / dichloromethane / 3 h / 75 °C
5.2: 0 - 20 °C

References:

BRISTOL-MYERS SQUIBB COMPANY;WROBLESKI, Stephen T.;JAGABANDHU, Das;DOWEYKO, Lidia M.;GUO, Junqing;HYNES, John;JIANG, Bin;KEMPSON, James;LIN, Shuqun;SPERGEL, Steven H.;TOKARSKI, John S.;WU, Hong;YANG, Bingwei Vera WO2012/125887, 2012, A1

6-bromo-4-hydroxypyrrolo[1,2-b]pyridazine-3-carbonitrile

1400580-13-3
2 suppliers
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1400580-14-4
19 suppliers
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References

934-05-4 Synthesis

934-05-4
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$8.00/1g

1400580-14-4
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References

Methyl 1-amino-4-bromo-1H-pyrrole-2-carboxylate methanesulfonate

1400580-12-2
3 suppliers
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1400580-14-4
19 suppliers
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References

1-(4-BROMO-1H-PYRROL-2-YL)-2,2,2-TRICHLORO-1-ETHANONE

72652-32-5
62 suppliers
$20.00/250 mg

1400580-14-4
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References