![](/CAS/GIF/140136-71-6.gif)
Benzene, 1-bromo-2-isothiocyanato-3,5-dimethyl- (9CI) synthesis
- Product Name:Benzene, 1-bromo-2-isothiocyanato-3,5-dimethyl- (9CI)
- CAS Number:140136-71-6
- Molecular formula:C9H8BrNS
- Molecular Weight:242.14
![2,4-DIMETHYLPHENYL ISOTHIOCYANATE](/CAS/GIF/39842-01-8.gif)
39842-01-8
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$10.00/1g
![Benzene, 1-bromo-2-isothiocyanato-3,5-dimethyl- (9CI)](/CAS/GIF/140136-71-6.gif)
140136-71-6
7 suppliers
$213.15/250MG
Yield:140136-71-6 71%
Reaction Conditions:
with 2,6-di-tert-butyl-4-methyl-phenol;copper(ll) bromide in tetrahydrofuran at 20; for 10 h;
Steps:
3.1.2 General Procedure for 2-haloarylisothiocyanate
General procedure: To a stirred solution of THF (2 ml), respective isothiocyanate(0.5 mmol) was added in slowly and followed byCuX2(1 eq) and BHT (3 eq) were added slowly and thereaction mixture was stirred for 6 h at room temperature.The progress of the reaction was investigated by TLC (5%ethylacetate in hexane). After finish the reaction, the reactionmixture was washed with water (4 ml) and ethylacetate(6 ml) for 3 times. Both organic and aqueous layerswere separated and the organic layer was concentrated byusing rotary evaporator and the crude mixture was purifiedby silica gel (60-120 mesh) column chromatography usingEthylacetate in Hexane as eluent to obtain a 2-halophenylisothiocyanate as oily liquid
References:
Mandapati, Usharani;Pinapati, Srinivasarao;Tamminana, Ramana;Rameshraju, Rudraraju [Catalysis Letters,2018,vol. 148,# 1,p. 418 - 423]